The Sheltzer Lab at CSHL

About the Lab

The Sheltzer Lab was founded in August 2015 at Cold Spring Harbor Laboratory.  We’re working to decipher the genetics of cancer progression using a variety of in silico, in vitro, and in vivo techniques.

We’re particularly interested in the role of aneuploidy in tumorigenesis. We’re developing novel systems to study genome dosage imbalances, in hopes of generating therapies that can specifically eliminate aneuploid cancers while leaving normal cells unharmed.


  • October, 2017 – our lab’s new paper on MELK and mitosis is up on bioRxiv.
  • September, 2017 – our lab’s new paper on prognostic genomic changes in cancer is up on bioRxiv.
  • March, 2017 – we’re currently looking to hire postdocs, students, and technicians to work on several projects in cancer biology.  Interested applicants should send a cover letter and CV to Dr. Sheltzer.
  • March, 2017 – our lab’s new paper investigating a breast cancer drug target using CRISPR has been published in eLife.
  • February, 2017 – Dr. Anand Vasudevan has joined the lab as a postdoc.  Anand previously studied rat models of Toxoplasma gondii infection, and will be looking at the effects of aneuploidy on cancer progression in vivo.